Disolcel®
Croscarmellose Sodium
Disolcel® (CCS) provides excellent dissolution properties in majority of tablet formulations. Typical use levels are between 0.5-3.0% only. Disolcel® has been used in pharmaceutical tablets, capsules and granules to aid in disintegration of dosage form and drug dissolution.
Effectiveness of Croscarmellose Sodium on Tablet Disintegration
Using the well-known fact that Dicalcium Phosphate tablets are poorly disintegrating, we compared different levels of Croscarmellose Sodium and their effects on disintegration time of Dicalcium Phosphate tablets as shown below.
| Croscarmellose Sodium,% | Disintegration Time |
|---|---|
| 0.10 | >>2Hr |
| 0.25 | 245 sec |
| 0.50 | 31 sec |
| 1.00 | 16 sec |
| 1.50 | 13 sec |
Effect of Settling Volumes in Disolcel® on Drug Dissolution:
The data below shows that formulation containing Disolcel® with higher settling volume, has faster drug dissolution that means speed up the drug released rate. (i.e the shorter T60%)
